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NQO1 enzymatic activity and LD50 of β-lap ± Dic in three different prostate cancer cell lines
| Cell Lines | NQO1 level (nmol cytochrome c reduced/min/mg protein)* | LD50 values of β-Lap (μM, 2 h) | |
|---|---|---|---|
| Dicoumarol (−) | Dicoumarol (+)§ | ||
| DU145 | 556 ± 18 | 3.0 ± 0.1 | 9.1 ± 0.6 |
| PC-3 | 107 ± 17 | 1.5 ± 0.1 | 20.0 ± 4.4 |
| LNCaP NQO1+ | 108 ± 21 | 2.7 ± 0.9 | > 20 |
| LNCaP NQO1− | 2.4 ± 0.1 | 11.8 ± 1.7 | ND |
Values are mean ± SEM; n = 6 per group.
Dicoumarol was administered at 40 μM concomitant with 2 h β-lap treatments.
