Table 3.

Somatostatin receptor subtype-binding affinity of somatostatin analogues.

Receptor subtype affinity [IC50, nM]
Compound	SSTR1	SSTR2	SSTR3	SSTR4	SSTR5
SMS-14	2.26	0.23	1.43	1.77	0.88
SMS-28	1.85	0.31	1.3	ND	0.4
Octreotide	1140	0.56	34	7030	7
Lanreotide	2330	0.75	107	2100	5.2
Pasireotide	9.3	1	1.5	>100	0.16

SMS, Somatostatin; ND, not determined.

[Data from Grozinsky-Glasberg S., Endocrine-Related Cancer 2008 Sep;15[3]:701-20].