Table 2.
The value of sCD14 in serum and BALF compared to CRP and WBC for diagnosing bacterial pneumonia in children.
| sCD14 serum | CRP | WBC | sCD14 BALF | |
|---|---|---|---|---|
| Sensitivity1 [%] | 93.6 | 80.7 | 64.5 | 41.9 |
| Specificity2 [%] | 100 | 100 | 96.8 | 96.8 |
| Diagnostic accuracy3 [%] | 97.94 | 93.6 | 86.0 | 78.5 |
| Area under the ROC curve [%] | 99.8 | 93.1 | 87.9 | 69.0 |
| Cut-off value | 8444 ng/ml | 30 mg/l | 14.0 × 109 | 55 ng/ml |
1 Sensitivity is defined as the probability that a patient with pneumonia shows elevated levels of the respective marker at the specific cut-off level.
2 Specificity is defined as the probability that a patient without pneumonia shows levels of the respective marker below the specific cut-off level.
3 Diagnostic accuracy is defined as the number of correctly positive categorized plus the number of correctly negative categorized as percentage of all.
4 The same diagnostic accuracy (97.9%) was reached for sCD 14 in serum at a cut-off value of 5429 ng/ml resulting in a sensitivity of 100% and a specificity of 96.8%.