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. 2010 Mar 26;6(3):e1000718. doi: 10.1371/journal.pcbi.1000718

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Daigle, Jr. et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) All pairwise covariances were calculated between 9105 genes; entries whose absolute values were greater than .25 were set to one and colored black (set to zero and colored white otherwise). (B) Binarized covariance matrix after hierarchical biclustering ( distance metric and complete linkage) to identify coordinated expression modules. The observed modularity is not due to chance, as an identical procedure applied to a randomized expression matrix showed no covariance blocks larger than a few genes (not shown).

Inline graphic — (A) All pairwise covariances were calculated between 9105 genes; entries whose absolute values were greater than .25 were set to one and colored black (set to zero and colored white otherwise). (B) Binarized covariance matrix after hierarchical biclustering ( distance metric and complete linkage) to identify coordinated expression modules. The observed modularity is not due to chance, as an identical procedure applied to a randomized expression matrix showed no covariance blocks larger than a few genes (not shown).