Table 3. Insulin resistance significant DE genes.

Symbol	Description	Direction	SAGAT PFER	FC PFER
FOSB*	FBJ murine osteosarcoma viral oncogene homolog B	Up
ACTG2	actin, gamma 2, smooth muscle, enteric	Down	0.0007	0.0007
FADS1*	fatty acid desaturase 1	Down	0.0022	0.0048
PMP2	peripheral myelin protein 2	Down	0.0034	0.0770
ATP1A2 *	ATPase, transporting, alpha 2	Down	0.0040	0.1620
CNN1	calponin 1, basic, smooth muscle	Down	0.0067	0.0114
CSN1S1	casein alpha s1	Down	0.0123	0.0004
SELE*	selectin E (endothelial adhesion molecule 1)	Up	0.0174	0.0006
CASQ2	calsequestrin 2 (cardiac muscle)	Down	0.0176	0.0238
FAM150B	family with sequence similarity 150, member B	Down	0.0188	0.0006
FASN *	fatty acid synthase	Down	0.0231	0.0610
FOS *	v-fos FBJ osteosarcoma viral oncogene homolog	Up	0.0242	0.0885
SRGN	serglycin	Up	0.0249	0.6952
CILP	cartilage intermediate layer protein	Up	0.0271	0.0420
CXCR4 *	chemokine (C-X-C motif) receptor 4	Up	0.0311	0.6058
PPBP*	pro-platelet basic protein (chemokine ligand 7)	Down	0.0325	0.0355
AADAC	arylacetamide deacetylase (esterase)	Up	0.0374	0.0019
ELOVL6 *	long chain fatty acid elongation	Down	0.0425	0.0734
IL6 *	interleukin 6 (interferon, beta 2)	Up	0.1340	0.0120

Significance was determined by running the Rank Products (RP) algorithm on ranked lists of genes derived from Affymetrix, Agilent, and Illumina microarray data. Genes were ranked by both fold change and SAGAT before applying RP; the PFER (per family error rate) is displayed for both cases. Only those genes with a PFER of .05 or smaller (achieved using SAGAT or fold change) are considered significant. Genes in normal font were significant using both fold change and SAGAT, genes in bold were identified only with SAGAT, and IL6 was found only with the fold change metric.

*Literature evidence implicates gene with insulin resistance, diabetes, or fatty acid metabolism.