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. 2010 Mar 26;5(3):e9910. doi: 10.1371/journal.pone.0009910

Table 1. Drug sensitivity in cells expressing the PDK1-IFPC::IFPN-AKT1 complex.

No. Drugs Known targets Drug sensitivity in cells expressing the PDK1-IFPC::IFPN-AKT1 complex*
1 LY294002 Pan PI3K, mTORC1 +
2 PI103 Pan PI3K, mTORC1 +
3 GDC0941 Pan PI3K, mTORC1 ++
4 TGX286 PI3Kβ/δ +++
5 Akti-1/2 AKT1, AKT2 ++
6 Rapamycin mTORC1 −

*“+++” indicates completely resistant. “−” indicates completely sensitive.