Figure 9. High-level workflow of reb2sac automated model abstraction engine.

The engine automatically generates an abstracted model by taking as inputs a detailed interaction-based model and, optionally, various targets and tolerances that can help set and adjust the level of abstraction. A list of available abstraction methods (which include graph-theoretical interaction-network analysis tools, dynamic reaction-level approximations, etc.) is sequentially checked and, if appropriate, the method is applied to the original detailed model—transforming it accordingly. This procedure is then repeated using the next method until the list of available methods is exhausted. (See Refs. [63],[64] for further description and explanation.)