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. Author manuscript; available in PMC: 2010 Mar 25.
Published in final edited form as: Mucosal Immunol. 2009 Sep 9;3(1):81–91. doi: 10.1038/mi.2009.112

Figure 6.

Figure 6

Reconstitution of Jα18−/− with invariant natural killer T (iNKT) cells from PD-L1−/− and PD-L2−/− mice. (a, b) iNKT cells were positively selected from the spleen of BALB/c, PD-L1−/−, and PD-L2−/− mice and adoptively transferred (3×106 cells) into ovalbumin (OVA)-sensitized Jα18−/− mice, which were then challenged with OVA IN on 3 consecutive days and assessed for AHR by measuring lung resistance (RL) and dynamic compliance (Cdyn) (a) or PenH (b). Non-recipient Jα18 and BALB/c mice were sensitized and challenged with OVA as control. Data are the mean±s.e.m., representative of three experiments (n= 5) with ** P<0.001 (recipients of PD-L1−/− vs. WT iNKT cells and recipients of PD-L2−/− vs. WT iNKT cells).