Figure 2.
Protein adsorption behaviors onto substrates coated with tyrosine-derived polymers. * P<0.05 vs. the other test groups in the graph. The adsorption of proteins from 5% fetal bovine serum (FBS) was examined on eight test polycarbonate surfaces by perfusion of FBS through the system at a flow rate of 24.2 µl/min for 60 minutes. Phosphate buffered saline (PBS) was then perfused through the system for 90 minutes to rinse off non-adherent proteins. The Voigt model19 was used to calculate the adsorbed protein mass in µg/cm2: 8% PEG copolymerized with DTE shows a significant decrease in adsorbed protein, but exhibits no protein repulsion when copolymerized with I2DTE or when polymerized in a terpolymer with 10% DT and DTE.