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. Author manuscript; available in PMC: 2010 Sep 25.
Published in final edited form as: Nature. 2010 Mar 17;464(7288):597–600. doi: 10.1038/nature08848

Figure 3. Insect TRPA1s are reactive electrophile sensors.

Figure 3

a–e. Representative responses of dTRPA1 (a–d) and agTRPA1 (e) expressed in oocytes. Left panels, currents at −60 and +60 mV. Perfusion buffer containing indicated chemical (a, c, d, 100 μM; b, e, 40 μM) was applied for 60–80 sec. 100 μM ruthenium red (RR) applied as noted. Right panels show I–V relationships at points marked on left panels. f, g, Ectopic dTRPA1 expression confers electrophile sensitivity upon motor neurons. f, Motor neuron-driven excitatory junction potentials (EJPs) from third instar larval muscles. g. Mean EJP frequencies. In controls, no EJPs were observed.