Figure 2. Peptide-specific memory CD8+ T cell responses to VACV in inbred and F1 mice.
Groups of C57Bl/6 (H-2b), DBA/2 (H-2d) and BDF1 (H-2b×d) were infected i.p. with 106 pfu VACV strain WR. Three months later CD8+ T cell responses in the spleen were measured by ICS. Percentages (A) and total numbers (C) of CD8+ T cells that produce IFN-γ in ex vivo stimulations with the indicated individual peptides from a representative experiment; data are means and SEM from groups of 4 mice. Ratios of responses in F1 mice compared with parent strains are shown based on percentages (B) and total numbers (D); data are means and SEM of 3 experiments.