- Intra-arterial injection |
- Right-to-left, bi-directional, or transient right- to-left cardiac shunts |
- Worsening or clinically unstable congestive heart failure |
- Acutemyocardial infarction or acute coronary syndromes |
- Ventricular arrhythmias or high risk for arrhythmias due to QT prolongation |
- Respiratory failure, as manifest by signs or symptoms of carbon dioxide retention or hypoxemia |
- Severe emphysema, pulmonary emboli or other conditions that cause pulmonary hypertension due to compromised pulmonary arterial vasculature |
- Hypersensitivity to perflutren, blood, blood products, or albumin. |