aHorizontal lines represent means. The mean left subgenual cingulate volume for patients with affective disorder who had a family history of affective disorder was 181 mm3 (SD=45); for patients with affective disorder who had no family history of the disorder, mean=239 mm3 (SD=43); for patients with schizophrenia, mean= 184 mm3 (SD=59); for normal comparison subjects, mean=226 mm3 (SD=51). The mean right subgenual cingulate volume for patients with affective disorder who had a family history of affective disorder was 225 mm3 (SD=73); for patients with affective disorder who had no family history of the disorder, mean=277 mm3 (SD= 89); for patients with schizophrenia, mean=232 mm3 (SD=105); for normal comparison subjects, mean=280 mm3 (SD=87).