Fig. 6.

Co-localization of PTP1D, PTP-MEG2 and PTP-PEST proteins in nestin-positive neural progenitor cells in the E13 mouse superior colliculus. Sagittal sections through the embryonic E13 superior colliculus were double-labeled with antibodies against PTPs and the neural progenitor marker nestin. Arrowheads indicate examples of double-labeled cells. PTP1D, PTP-MEG2 and PTP-PEST epitopes partially co-localize with nestin-positive neural progenitor cells. Because the nestin- and PTP1C antibodies originated from the same species (both mouse, IgG), it was not possible to analyse the co-localization of the PTP1C protein with nestin-positive precursor cells. Note that the antibodies directed at intracellular PTPs label mainly nuclei/perikarya of collicular cells; both markers reveal an incomplete overlapping expression pattern (merge). IZ intermediate zone, VZ/SVZ ventricular zone/subventricular zone. Scale bar 50 μm