Fig. 6.
Increased levels of cytochrome c require higher levels of neuroglobin to block activation of caspase 3. Time course of caspase-3 activation is shown for three different values of cytochrome c concentrations: a 0.2 μM, b 0.5 μM, c 1 μM. Neuroglobin concentration is kept fixed at 0.1 μM. Each line shows the time-course of caspase-3 activation at the single cell level. Caspase 3 activation is normalized by the maximum. Time is measured in monte carlo (MC) simulations steps. 1 MC step = 10−4 s. Note the variation in time-scales in caspase 3 activation as the cytochrome c concentration is increased