Table 1.
Clinical and demographic characteristics of study cohort before HCT, at 6 months, 1 year, 2 years, and 3 years after HCT
| Pre-HCT (n = 312) | 6 mo (n = 165) | 1 y (n = 158) | 2 y (n = 149) | 3 y (n = 153) | |
|---|---|---|---|---|---|
| Median age at referent HCT,*s y (range) | 48 (18-78) | 50 (19-78) | 48 (19-78) | 49 (19-78) | 48 (18-78) |
| Sex, n (%) | |||||
| Male | 173 (55) | 84 (51) | 76 (48) | 75 (50) | 80 (52) |
| Female | 139 (45) | 81 (49) | 82 (52) | 74 (50) | 73 (48) |
| Race/ ethnicity, n (%) | |||||
| White (non-Hispanic) | 202 (65) | 105 (64) | 104 (66) | 96 (64) | 101 (66) |
| Hispanic/Latino | 57 (18) | 28 (17) | 29 (18) | 27 (18) | 28 (18) |
| African American | 22 (7) | 15 (9) | 11 (7) | 9 (6) | 8 (5) |
| Asian | 26 (8) | 12 (7) | 11 (7) | 12 (8) | 11 (7) |
| Other | 5 (2) | 5 (3) | 3 (2) | 5 (3) | 5 (3) |
| Marital status at pre-HCT, n (%) | |||||
| Married/partnered | 203 (65) | 115 (70) | 107 (68) | 104 (70) | 105 (69) |
| Single | 64 (20) | 27 (16) | 32 (20) | 28 (19) | 28 (18) |
| Divorced/widowed/separated | 45 (14) | 23 (14) | 19 (12) | 17 (11) | 20 (13) |
| Education, highest attained at time of referent HCT, n (%) | |||||
| Did not complete high school (HS) | 18 (6) | 8 (5) | 10 (6) | 6 (4) | 6 (4) |
| HS graduate | 53 (17) | 27 (16) | 24 (15) | 21 (14) | 18 (12) |
| Some college | 105 (34) | 51 (31) | 43 (27) | 44 (30) | 43 (28) |
| Bachelor's degree | 71 (23) | 38 (23) | 40 (25) | 39 (26) | 44 (29) |
| Postgraduate degree | 64 (21) | 41 (25) | 41 (26) | 39 (26) | 42 (27) |
| Unknown | 1 (0.3) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Annual household income at time of referent HCT, n (%) | |||||
| Less than $20 000 | 24 (8) | 12 (7) | 15 (9) | 10 (7) | 13 (8) |
| $20 000-$49 000 | 78 (25) | 38 (23) | 30 (19) | 29 (19) | 31 (20) |
| $50 000-$74 000 | 98 (31) | 47 (28) | 49 (31) | 43 (29) | 39 (25) |
| $75 000-$100 000 | 47 (15) | 26 (16) | 25 (16) | 22 (15) | 26 (17) |
| More than $100 000 | 63 (20) | 41 (25) | 38 (24) | 44 (30) | 44 (29) |
| Unknown | 2 (.6) | 1 (.6) | 1 (.6) | 1 (.7) | 0 (0) |
| Body mass index in kg/m2 at pre HCT, median (range) | 26.2 (17.0-50.2) | 26.3 (18.5-50.2) | 26.5 (19.1-47.2) | 25.9 (17.0-50.2) | 26.3 (18.1-50.2) |
| Change in body mass index from pre-HCT level, median (range) | NA | −1.3 (−14.9-12.0) | −0.9 (−15.3-10.5) | −0.6 (−17.5-13.5) | 0 (−10.4-15.3) |
| Primary diagnosis, n (%) | |||||
| Non-Hodgkin lymphoma | 86 (28) | 51 (31) | 45 (28) | 46 (31) | 50 (33) |
| Acute myelogenous leukemia | 66 (21) | 31 (19) | 31 (20) | 31 (21) | 33 (22) |
| Multiple myeloma | 60 (19) | 40 (24) | 35 (22) | 28 (19) | 28 (18) |
| Hodgkin lymphoma | 25 (8) | 12 (7) | 13 (8) | 13 (9) | 12 (8) |
| Acute lymphocytic leukemia | 23 (7) | 8 (5) | 8 (5) | 6 (4) | 6 (4) |
| Myeloproliferative disorder | 18 (6) | 9 (5) | 9 (6) | 10 (7) | 9 (6) |
| Other | 34§ (11) | 14 (8) | 17 (11) | 15 (10) | 15 (10) |
| High risk of relapse at referent HCT, n (%) | 162 (52) | 80 (48) | 80 (51) | 75 (50) | 77 (50) |
| Disease in remission, n (%) | 107 (36) | 139 (84) | 135 (85) | 129 (87) | 130 (85) |
| Stem cell source,†n (%) | |||||
| Autologous only | 170 (54) | 103 (62) | 97 (61) | 92 (62) | 93 (61) |
| Allogeneic | 142 (46) | 62 (38) | 61 (39) | 57 (38) | 60 (39) |
| Chronic GVHD,‡ n (%), among allogeneic HCT patients | NA | 22 (35) | 30 (49) | 33 (58) | 33 (55) |
| Number of HCT, n (%) | |||||
| 1 | 253 (81) | 140 (85) | 132 (84) | 125 (84) | 131 (86) |
| 2 | 57 (18) | 25 (15) | 26 (16) | 24 (16) | 21 (14) |
| 3 | 2 (.6) | 0 (0) | 0 (0) | 0 (0) | 1 (.6) |
| Conditioning regimen, n (%) | |||||
| Total body irradiation | 134 (43) | 62 (38) | 56 (35) | 57 (38) | 59 (39) |
| Chemotherapy based | 311 (99) | 164 (99) | 157 (99) | 148 (99) | 152 (99) |
NA indicates not applicable.
*
Referent HCT refers to the specific transplantation (not necessarily the first) that led to a patient's study enrollment.
†
Patients who received at least one allogeneic HCT were categorized under allogeneic HCT.
‡
Self-reported.
§
Chronic myelogenous leukemia (n = 18); severe aplastic anemia (n = 6); chronic lymphocytic leukemia (n = 3); other-amyloidosis (n = 2); 1 each of amyloidosis, hypereosinophillic syndrome, other-leukemia, POEMS syndrome, renal cancer.