Table 2.
Modifying factors of the longitudinal trends of QOL domains for autologous transplantation (HCT) patients
| Modifying factor* | Percent change† (effect size)‡ in QOL domain score by modifying factor |
|||||||
|---|---|---|---|---|---|---|---|---|
| QOL domain | ||||||||
| Physical |
Psychological |
Social |
Spiritual |
|||||
| Pre-HCT | Post-HCT | Pre-HCT | Post-HCT | Pre-HCT | Post-HCT | Pre-HCT | Post-HCT | |
| Age at referent HCT, per year increase | — | −0.21%** (0.01) | 0.63%†† (0.02) | — | 0.79%†† (0.03) | 0.47%‡‡ (0.02) | — | — |
| Race/ethnicity | ||||||||
| African American, Hispanic (vs white, Asian, other) | — | −4.0%** (0.18) | — | — | — | — | — | — |
| Asian, other (vs white, Hispanics, African American) | — | — | — | — | — | — | — | 15.4%‡‡ (0.70) |
| Married§ (vs single, divorced/widowed/separated) | — | — | — | — | — | — | 9.9%** (0.34) | — |
| Annual household income less than $75 000 (vs $75 000 or more) | — | −10.1%‡‡ (0.45) | — | — | — | −8.4%** (0.29) | — | — |
| Education | ||||||||
| Less than or more than high school (vs high school only) | — | — | −22.4%†† (0.69) | −11.2%** (0.40) | −14.0%** (0.49) | −11.8%** (0.41) | — | — |
| Bachelor degree or higher (vs less than Bachelor degree) | — | — | — | — | — | — | −12.1%‡‡ (0.47) | −11.9%‡‡ (0.58) |
| BMI§ in kg/m2, per unit increase | — | — | — | — | — | −0.16%‡‡ (0.01) | — | — |
| Change in BMI from pre-HCT level,§,‖ per unit decrease | NA | — | NA | −0.73%‡‡ (0.03) | NA | — | NA | — |
| Primary diagnosis | ||||||||
| Group¶,# 2,4,5,7 (vs group 3) | −20.8%†† (−1.27) | — | — | — | — | — | — | — |
| Groups 2,3 (vs groups 4,5,7) | — | — | — | −9.5%** (0.42) | — | — | — | — |
| High risk of relapse at HCT (vs low risk) | — | — | −8.1%** (0.28) | — | — | — | — | — |
| One transplant (vs more than 1 transplant) | — | — | −16.4%‡‡ (0.52) | — | — | — | — | 8.3%** (0.39) |
— indicates statistically non-significant factors (P > .05); therefore percent change and ES are not shown. NA indicates not applicable.
Referent groups are shown in parentheses. Other factors examined that were nonsignificant in the multivariate GEE regression include: sex, disease relapse status, pre-HCT exposure to total body irradiation and chemotherapy-based conditioning agents.
Percent change is calculated as [(expected level of the index group − expected level of the referent group)/(expected level of the referent group)] × 100. For age and BMI, expected levels corresponding to their means at pre-HCT were used as referent levels. For post-HCT, the average of the 4 time points is reported. Positive percent change indicates more favorable QOL in the index group.
Effect size at a particular time point is computed as the absolute value of (expected level of the index group − expected level of the referent group)/observed common SD at that time point. At post-HCT, the average effect size of the 4 time points is reported.
Time-varying: values concurrent to QOL scores were used.
BMI at follow-up minus BMI at pre-HCT.
Group 1: ALL; Group 2: AML, APL; Group 3: Amyloidosis, CLL, Hypereosinophilic syndrome, other-Amyl, POEMS, renal cancer, SAA, CML; Group 4: HD'; Group 5: LBL, NHL, Other-lymph; Group 6: MDS, MPD, myelofibrosis, other-MPP; Group 7: MM.
Disease groups 1 and 6 did not occur under autologous HCT.
Value of P < .05.
Value of P < .001.
Value of P < .01.