Table 3.
Modifying factors of the longitudinal trends of QOL domains in allogeneic transplantation (HCT) patients
| Modifying factor* | Percent change† (effect size)‡ in QOL domain score by modifying factor |
|||||||
|---|---|---|---|---|---|---|---|---|
| QOL domain | ||||||||
| Physical |
Psychological |
Social |
Spiritual |
|||||
| Pre-HCT | Post-HCT | Pre-HCT | Post-HCT | Pre-HCT | Post-HCT | Pre-HCT | Post-HCT | |
| Age at referent HCT, per year increase | — | −0.69%** (0.03) | — | — | 0.64%†† (0.02) | 0.75%†† (0.02) | — | — |
| Race/ethnicity | ||||||||
| Asian, other (vs white, Hispanic, African American) | — | — | — | — | −14.5%‡‡ (0.53) | −15.1%‡‡ (0.50) | — | — |
| White (vs Hispanic, African American, Asian, other) | — | — | — | — | — | — | −10.0%‡‡ (0.40) | — |
| Annual household income | ||||||||
| $100 000 or less (vs more than $100 000) | — | — | 9.5%†† (0.37) | — | — | — | — | — |
| $75 000 or less (vs more than $75 000) | — | — | — | — | −13.7%‡‡ (0.54) | −12.9%†† (0.45) | — | — |
| BMI§ in kg/m2, per unit increase | 1.0%†† (0.05) | 1.1%** (0.05) | — | 0.43‡‡ (0.02) | — | — | — | — |
| Change in BMI from pre-HCT level,§,‖ per unit decrease | NA | — | NA | −0.71%†† (0.03) | NA | −0.83% (0.03) | NA | — |
| Primary diagnosis | ||||||||
| Groups¶ 1,4,6 (vs groups 2,3,5,7) | −10.0%** (0.52) | — | — | — | — | — | −9.8%‡‡ (0.42) | — |
| Groups 1,4 (vs groups 2,3,5,6,7) | — | −17.0%** (0.75) | — | — | — | — | — | — |
| Groups 3,5,6,7 (vs groups 1,2,4) | — | — | 12.0%‡‡ (0.40) | — | — | — | — | — |
| Groups 6,7 (vs groups 1,2,3,4,5) | — | — | — | 10.6%†† (0.39) | — | — | — | — |
| Groups 2,4,6 (vs groups 1,3,5,7) | — | — | — | — | −11.7%‡‡ (0.44) | — | — | — |
| Disease in remission§ (vs in relapse) | 8.3%‡‡ (0.44) | — | — | — | — | — | — | — |
| Chronic GVHD§,# (vs no chronic GVHD) | NA | −11.2%** (0.51) | NA | −8.0%‡‡ (0.32) | NA | −10.6%‡‡ (0.37) | NA | −7.8%‡‡ (0.34) |
| Busulfan (vs no busulfan) | — | −17.6%** (0.79) | — | — | — | — | — | — |
— indicates statistically nonsignificant factors (P > .05); therefore percent change and ES are not shown. NA indicates not applicable.
Referent groups are shown in parentheses. Other factors examined that were nonsignificant in the multivariate GEE regression include: sex, marital status, education, disease relapse status, risk of relapse at HCT, number of transplants, pre-HCT exposure to total body irradiation.
Percent change is calculated as [(expected level of the index group — expected level of the referent group)/(expected level of the referent group)] × 100. For age and BMI, expected levels corresponding to their means at pre-HCT were used as referent levels. For post-HCT, the average of the 4 time points is reported. Positive percent change indicates more favorable QOL in the index group.
Effect size at a particular time point is computed as the absolute value of (expected level of the index group − expected level of the referent group)/observed common SD at that time point. At post-HCT, the average effect size of the 4 time points is reported.
Time-varying: values concurrent to QOL scores were used.
BMI at follow-up minus BMI at pre-HCT.
Group 1: ALL; Group 2: AML, APL; Group 3: Amyloidosis, CLL, Hypereosinophilic syndrome, other-Amyl, POEMS, renal cancer, SAA, CML; Group 4: HD'; Group 5: LBL, NHL, Other-lymph; Group 6: MDS, MPD, Myelofibrosis, other-MPP; Group 7: MM.
Self-reported.
Value of P < .001.
Value of P < .05.
Value of P < .01.