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. Author manuscript; available in PMC: 2011 Feb 17.
Published in final edited form as: Bioconjug Chem. 2010 Feb 17;21(2):372–384. doi: 10.1021/bc900473v

Figure 3.

Figure 3

Figure 3

Inhibition of radioligand binding by dendrimer nucleoside conjugates in membranes of CHO cells expressing the human A1 (A) and A3 (C) ARs and HEK-293 cells expressing the human A2AAR (B). Inhibition curves at three ARs are shown for the dendrimer-nucleoside conjugates 6 and 7, in which the linkage to an azide-derivatized dendrimer was formed by click cycloaddition, for the mixed nucleoside/nucleotide conjugate 8 and for the amide-linked nucleoside conjugate 12. Both 6 and 7 were highly selective for the hA3AR in comparison to the hA1 and hA2AARs.