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. Author manuscript; available in PMC: 2010 Mar 26.
Published in final edited form as: Methods Mol Biol. 2009;590:165–176. doi: 10.1007/978-1-60327-378-7_10

Fig. 10.1.

Fig. 10.1

Overview of the MeDIP protocol. The genomic DNA is sonicated into small fragments and then immunoprecipitated with an antibody directed against 5-methylcy-tidine. Input DNA and methylated DNA (black circle) can be differentially labeled with Cy5 (red) and Cy3 (green) and co-hybridized as a two-color experiment on microarrays, or used for data validation.