Skip to main content
. Author manuscript; available in PMC: 2010 Mar 26.
Published in final edited form as: Biochim Biophys Acta. 2008 Dec 30;1790(9):920–924. doi: 10.1016/j.bbagen.2008.12.004

Fig. 1.

Fig. 1

An epigenetic model depicting the influence of breast cancer-associated fibroblasts on the non-cancerous breast epithelial cells (MCF10A). (A) After cocultured with cancer-associated fibroblasts (CAF), CST-6 (and perhaps other breast cancer-associated genes) became hypermethylated and silenced (marked in red). Epigenetic perturbation was mediated by an activation of AKT1 signaling pathway. (B) In contrast, exposure to normal fibroblasts (NF) confers negligible levels of epigenetic perturbations and AKT1 kinase activation in the same MCF10A cells (marked in light blue).