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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Glia. 2010 Apr;58(5):572–587. doi: 10.1002/glia.20946

Fig. 5.

Fig. 5

Larger synapses had more docked presynaptic vesicles. (a) Docked vesicle (purple arrow) in the presynaptic bouton associated with a thin spine from the mild case. Also noted, though not quantified, is a polyribosome in the spine head (yellow arrow). (b) Docked vesicle (purple arrow) at a shaft synapse in the mild case (scale bar is for a and b). 3D reconstructions show docked vesicles (purple) at (c) thin and (d) mushroom spines in the mild case and (e) thin and (f) mushroom spines in the moderate case, and (g) a multisynaptic spine in the severe case (scale cube in f is for c–g). (h) Docked vesicle number correlated with PSD area in the mild (r = 0.69, P < 0.0001) and moderate (r = 0.68, P < 0.0001) cases.