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qRT-PCR analyses of HRI mRNA after heme depletion or repletion of untreated or PB-treated C57BL/6J HRI (−/−; KO) hepatocytes and corresponding HRI (+/+; WT) controls. For experimental details, see Materials and Methods. Statistically significant differences were observed between the two mean ± S.D. values from 3 separate experiments each marked with the same symbol as follows: #, p < 0.001; §, p < 0.001; or as shown.
