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Bimolecular rates of inhibition (ki) for hCE1 and nerve agent analogs. Plotted as log ki, hCE1 exhibits strong enantiomeric PR preference for soman and cyclosarin analogs, with only slight PS sarin analog selectivity. Dissociation constants (Kd) are similar to authentic nerve agents, whereas phosphorylation rates (k2) are 2 to 3 orders of magnitude slower. (n = 3, S.E.)
