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. 2010 Apr;77(4):508–516. doi: 10.1124/mol.109.062356

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Fig. 6. — hCE1 reactivation after inhibition by racemic bona fide OP nerve agents or stereospecific nerve agent analogs. A, spontaneous reactivation of racemic bona fide OP agents. Reactivation only occurs with sarin (■), with a half-time of reactivation of 45 h (n = 5, S.D.). Soman (●) and cyclosarin (♦) remained permanently inhibited. B, DAM-assisted reactivation with racemic bona fide nerve agents. Reactivation is only measured against sarin (■) with a half-time of reactivation of 41 min (n = 3, S.E.). Soman (●) and cyclosarin (♦) did not reactivate. C, DAM-assisted reactivation of sarin analogs. The P_S isomer (■) reactivates with a half-time of 30 min (n = 3, S.E.). P_R sarin (□) analog did not reactivate. D, DAM-assisted reactivation of soman analogs. The greatest reactivation was measured in the P_S (○) enantiomer, whereas the P_R (●) analog remained inhibited. E, DAM, assisted reactivation of cyclosarin analogs. Negligible reactivation was measured for either P_S (♢) or P_R (♦) cyclosarin analog. F, determination of aging with P_S nerve agent analogs; no aging was measured for the P_S species.