Fig. 8.

IREVEDEC and Penetratin-VEDEC peptides increase whole-cell currents in mouse podocytes. Whole-cell recordings were made from differentiated mouse podocytes treated with R-PE or IREVEDEC peptide using PULSin (A) or podocytes treated with penetratin, or penetratin-VEDEC peptides (B). The recording electrode contained 5 μM free Ca²⁺, and currents were evoked by a series of depolarizing steps from a holding potential of −60 mV. A, top, representative whole-cell currents. Bottom, bar graph shows mean ± S.E.M. of whole-cell currents at +60 mV with n = 33 cells in each group (for IREVEDEC peptides) and 11 cells in each group for penetratin experiments. ∗, P < 0.05.