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CocE-L169K/G173Q protection against cocaine-reinforced operant responding in Sprague-Dawley rats. CocE-L169K/G173Q (1 mg) was given as a pretreatment to cocaine self-administration sessions at the times indicated. Rats in the saline substitution condition received no cocaine from nose-pokes during the session. ***, one-way ANOVA F(2,12) = 27.4; Bonferroni post test, p < 0.001. *, Student's t test p < 0.05.
