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. 2010 Apr;77(4):539–546. doi: 10.1124/mol.109.062885

Fig. 2.

Fig. 2.

Current and fluorescence responses from the ρ1 receptor labeled with A5m at the K217C site. Current and fluorescence responses from receptors activated by 1 μM GABA in the absence and presence of 20 μM 3α5βP or 3α5βPOH (A), 3α5βPS or 3α5αPS (B), or β-estradiol or 10 μM picrotoxinin (PTXnin) (C). The top traces show currents (I), and the bottom traces show the concomitant changes in fluorescence (F). The modulators are sorted according to their proposed classification into groups. All drugs inhibit the electrophysiological response, but only 3α5βPS and 3α5αPS reduce the change in fluorescence (shown with dotted lines). D, the summary of effects on electrophysiology and fluorescence responses. ∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001.