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Phe656 is located in close proximity to Val653 on an adjacent subunit of the hERG1 channel. Structural model for the hERG1 pore based on the MthK channel [3]. The S5-S6 regions of three subunits are shown. The inset provides an expanded view of the proximity and orientation of one Phe656 residue relative to one Val653 residue located on an adjacent subunit.
