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A653R hERG1 channels are constitutively open. Top panel illustrates the pulse protocol used to activate currents, shown in lower three panels, that were recorded from an uninjected oocyte or oocytes injected with WT or A653R hERG1 cRNA. Unlike WT hERG1 currents, A653R channels do not deactivate. Oocytes were bathed in 96 K external solution.
