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. Author manuscript; available in PMC: 2010 Mar 26.
Published in final edited form as: Mutat Res. 2005 Aug 25;576(1-2):132–154. doi: 10.1016/j.mrfmmm.2004.10.014

Table 3.

Murine models of pancreatic cancer

Name of model Background strain Primary site Primary histology Average # of tumors/mouse Age (months) Metastasis References
Simian Virus 40 transforming antigen (SV40 TAg) models
 Ela-1-SV40 TAg C57BL/6 X SJL Exocrine pancreas Acinar cell carcinoma 100 3–7 Yes (rare) [64]
 Ela-1-SV40 TAg (T1-127, ET Mice) C57BL/6 Exocrine pancreas Acinar cell carcinoma 100 3–7 Yes [65]
 MET (ET X MUC1.Tg) C57BL/6 Exocrine pancreas Acinar cell carcinoma 100 4–6 Yes [67,68]
c-Myc model
 Ela-1-c-Myc C57BL/6 X SJL Exocrine pancreas Acinar/ductal adenocarcinoma 10 2–7 Yes [69]
Transforming growth factor-alpha (TGF-α) models
 MT-TGFα –hGH C57BL/6 X SJL Exocrine pancreas Pseudoductular metaplasia Multifocal 4–7 No [70]
 Ela-1-TGFα-hGH C57BL/6 Exocrine pancreas Acinar-to-ductal metaplasia 107 >1 year No [71,72]
 Ela-1-TGFα-hGH X P53+/− C57BL/6 X Balb/c Exocrine pancreas Acinar-to-ductal metaplasia 90 7–13 No [72]
 Ela-1-TGFα-hGH X P53−/− C57BL/6 X Balb/c Exocrine pancreas Acinar-to-ductal metaplasia 22 2–3 Yes [72]
Activated KrasG12D X Ink4a/Arf deficient model
 Pdx1-Cre;Ink4a/Arflox/+ FVB/n N.R. N.R. 0 2–6 No [73]
 LSL-KrasG12D;Ink4a/Arflox/lox FVB X 129/Sv Exocrine pancreas Ductal PanIN lesions Multifocal 2–6 No [73]
 Pdx1-Cre;LSL-KrasG12D;Ink4a/Arflox/lox FVB X 129/Sv Exocrine pancreas Ductal adenocarcinoma Multifocal 2–3 Yes [73]

N.R., not reported.