Figure 7.

Activation of micro-glial cells in the D2 retina. Fixed tissue sections of retina from both D2 and B6 mice at the age of 2 M, 4 M and 6 M were collected and immunolabeled for the protein, Iba1 (green). An elevated level of antibody binding to Iba1 was detected in the GCL and IPL in D2 retinas at 4 M when compared to 2 M. At 6 M, the labeling was further elevated and now more extensive from the GCL to the OPL. Compared to 2 M retinas from the D2 mice, Iba1-labeled micro-glial cells were less ramified with round somata at 4 and 6 M of age. These changes were not evident in age-matched B6 retinas. Bar: 20 μM.

Abbreviations: GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer.