Table 2.
Up-regulated genes in DBA/2J mouse retina (2 M vs 4 M).
| Accession number | Gene name | Fold change | Location | Type |
|---|---|---|---|---|
| Immune response/Inflammatory disease | ||||
| NM_009780 | Complement component 4B (C4B) | 2.0 | Extracellular space | Other |
| NM_007902 | Endothelin 2 (EDN2) | 3.2 | Extracellular space | Growth factor |
| NM_024406 | Fatty acid binding protein 4, adipocyte (FABP4) | 3.5 | Cytoplasm | Transporter |
| AK011851 | Guanine nucleotide binding protein (G protein), alpha 13 (GNA13) | 2.0 | Plasma membrane | Enzyme |
| NM_008491 | Lipocalin 2 (LCN2) | 4.3 | Extracellular space | Transporter |
| NM_013825 | Lymphocyte antigen 75 (LY75) | 2.0 | Plasma membrane | Other |
| NM_017372 | Lysozyme (renal amyloidosis) (LYZ) | 2.4 | Extracellular space | Enzyme |
| NM_010776 | Mannose-binding lectin (protein C) 2, soluble(opsonic defect)(MBL2) |
2.8 | Extracellular space | Other |
| AK020928 | Melan-A (MLANA) | 2.5 | Plasma membrane | Other |
| NM_023258 | PYD and CARD domain containing (PYCARD) | 2.1 | Cytoplasm | Transcription regulator |
| NM_027852 | Retinoic acid receptor responder (tazarotene induced) 2 (RARRES2) | 2.4 | Plasma Membrane | Transmembrane receptor |
| NM_007734 | Collagen, type IV, alpha 3 (Goodpasture antigen) (COL4A3) | 2.2 | Extracellular Space | Enzyme |
| Neurological disease | ||||
| NM_144784 | Acetyl-Coenzyme A acetyltransferase 1 (ACAT1) | 2.1 | Cytoplasm | Enzyme |
| NM_007670 | Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B) | 2.0 | Nucleus | Transcription regulator |
| NM_172119 | Deiodinase, iodothyronine, type III (DIO3) | 4.2 | Plasma membrane | Enzyme |
| K01347 | Glial fibrillary acidic protein (GFAP) | 2.4 | Cytoplasm | Other |
| NM_008128 | Gap junction protein, beta 6, 30 kDa (GJB6) | 5.2 | Plasma membrane | Transporter |
| NM_172778 | Monoamine oxidase B (MAOB) | 2.2 | Cytoplasm | Enzyme |
| NM_198190 | Neurotrophin 5 (NTF5) | 2.2 | Extracellular space | Growth factor |
| NM_009215 | Somatostatin (SST) | 2.1 | Extracellular space | Other |
| Cell signaling/Gene expression | ||||
| AK077820 | Aspartyl-tRNA synthetase (DARS) | 3.0 | Cytoplasm | Enzyme |
| AJ306425 | Hemochromatosis (HFE) | 2.1 | Plasma membrane | Transmembrane receptor |
| NM_010125 | E74-like factor 5 (ets domain transcription factor) (ELF5) | 3.3 | Nucleus | Transcription regulator |
| BC046759 | High-mobility group box 2 (HMGB2) | 2.1 | Nucleus | Transcription regulator |
| AB019029 | Mediator complex subunit 14 (MED14) | 2.4 | Nucleus | Transcription regulator |
| Cell death | ||||
| NM_008183 | Glutathione S-transferase M1 (GSTM1) | 2.3 | Cytoplasm | Enzyme |
| X80339 | SIX homeobox 1 (SIX1) | 2.4 | Nucleus | Transcription regulator |