TABLE 4.

Pharmacokinetics of ABC294640

Mice were given 50 mg/kg ABC294640·HCl in 0.375% Polysorbate-80 intravenously or by oral gavage Plasma was harvested at times between 1 min and 7 h, and ABC294640 levels were determined as described in Materials and Methods. Values represent the mean ± S.E.M. (n = 3 per group).

Route	AUC0→∞	AUC0→∞	tmax	Cmax	Cmax	t1/2
	μg · h/ml	μM · h	h	μg/ml	μM	h
Intravenous	56.9	137	0	31.1	74	1.4
Oral	37.5	90.1	0.25	8	19	4.5

AUC, area under the curve.