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. 2010 Apr;333(1):23–33. doi: 10.1124/jpet.109.160192

Fig. 3.

Fig. 3.

Lack of effect of GGTI-2Z/lovastatin treatment on membrane localization of a farnesylated GFP construct. HEK293 cells were transiently transfected with pRK7.GFP.H-Ras.CaaX plasmid, followed by treatment with prenylation inhibitors as shown for 16 h. FTI-1/lovastatin treatment inhibited H-Ras.CaaX localization at the plasma membrane, whereas GGTI-2Z/lovastatin treatment did not affect the localization even at 6 μM GGTI-2Z concentration. Results are representative of three independent experiments. DAPI, 4′,6-diamidino-2-phenylindole.