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. 2010 Apr;333(1):140–151. doi: 10.1124/jpet.109.162271

Fig. 7.

Fig. 7.

Hepatic mRNA expression of glucose- and fatty acid-related genes in wild-type and Nrf2-null mice after STZ. Total RNA isolated from livers of control and STZ-treated wild-type and Nrf2-null mice on day 10 were evaluated for mRNA expression of gluconeogenesis genes glucose-6-phosphatase and PEPCK (A); glycolysis genes glucokinase and liver-type pyruvate kinase (B); and fatty acid synthesis/metabolism genes stearoyl-CoA desaturase-1, malic enzyme-1, fatty acid synthase, and fatty acid translocase (CD36) (C). Data were normalized to wild-type controls and presented as mean relative expression ± S.E. (n = 3–6). Black bars represent wild-type mice, and gray bars represent Nrf2-null mice. Asterisks (∗) represent statistically significant differences (p < 0.05) compared with control mice of that genotype. Daggers (†) represent a statistically significant difference (p < 0.05) between wild-type and Nrf2-null mice with the same treatment.