Figure 3. NOD.DO mice have a diabetogenic T cell repertoire and functional Tregs.

(A) Purified splenic T cells (5 × 10⁶/mouse) from 22-week-old female NOD or NOD.DO mice were transferred into female NOD.scid mice. Recipient mice were monitored for diabetes development by measurement of urine glucose levels. (B) As in A, except CD25-depleted T cells were transferred into recipients that were injected with α-CD25 at the time of transfer.