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. 2010 Mar 15;120(4):1140–1150. doi: 10.1172/JCI41329

Figure 5. Summary of disease biomarkers during chronic administration of P188 in GRMD animals.

Figure 5

(A) Outline of study design for the chronic administration of P188 (n = 4) or saline (n = 4) in GRMD animals. (B–E) Serum chemistry data from samples take biweekly throughout the chronic infusion period; shown are (B) cTnI (dashed line indicates wild-type canine values), (C) CK, (D) aspartate transferase (AST) and alkaline phosphatase (ALP), and (E) blood urea nitrogen (BUN) and creatinine. Values are shown as mean ± SEM; 4–8 animals per group. *P < 0.05, significant treatment effect by 2-way ANOVA analysis.