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. 2010 Mar 24;120(4):1056–1068. doi: 10.1172/JCI41563

Figure 8. Sirt1 regulates COX2 expression in RMICs in vivo.

Figure 8

(A) Representative immunofluorescence images show COX2 induction (red) in the renal medulla of the obstructed kidney of wild-type mice 3 days after UUO. Costaining further shows induced COX2 (red) in RMICs between AQP2-positive (green) collecting ducts (right panel). (B) Immuno­blot for COX2 expression in the entire kidney of Sirt1+/+ and Sirt1+/– mice 3 days after UUO (n = 5, densitometry, *P < 0.05 versus obstructed kidney of Sirt1+/+ mice). (C) Wild-type mice were treated with vehicle or Sirt1 activator SRT1720 (100 mg/kg/d) for 5 days. Immunofluorescence costaining shows that SRT1720 induces COX2 expression (red) in RMICs between AQP2-positive (green) collecting ducts. (D) COX2 expression in the entire kidney of vehicle or SRT1720-treated mice was examined by immunoblot (n = 4, densitometry, *P < 0.05 versus vehicle-treated mice).