Tables V.
Odds ratios for association of the slopes of PlGF/sVEGFR-1, PlGF/s-Eng, PlGF/(s-Eng x sVEGFR-1) ratios and the s-Eng x sVEGFR-1 product between the first and second trimesters with the subsequent development of preterm PE, term PE, and delivery of an SGA neonate
| Normal Pregnancy | Preterm preeclampsia | Term preeclampsia | SGA | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | n | 95%CI | n | OR | 95%CI | n | OR | 95%CI | ||
| PlGF/s-Eng slope between the 1st and 2nd trimesters | ||||||||||
| Below median | 101 | 15 | 7.68 | 1.7-34.74 | 28 | 2.46 | 1.15-5.26 | 86 | 1.47 | 0.95-2.26 |
| Above median | 100 | 2 | 1 | Reference | 11 | 1 | Reference | 59 | 1 | Reference |
| PlGF/sVEGFR-1 slope between the 1st and 2nd trimesters | ||||||||||
| Below median | 101 | 13 | 3.28 | 1.02-10.59 | 19 | 0.83 | 0.41-1.67 | 76 | 1.13 | 0.73-1.74 |
| Above median | 100 | 4 | 1 | Reference | 20 | 1 | Reference | 69 | 1 | Reference |
| PlGF/(s-Eng x sVEGFR-1) slope between the 1st and 2nd trimesters | ||||||||||
| Below median | 100 | 13 | 3.71 | 1.14-12.11 | 22 | 1.20 | 0.59-2.45 | 71 | 0.99 | 0.64-1.53 |
| Above median | 101 | 4 | 1 | Reference | 17 | 1 | Reference | 74 | 1 | Reference |
| s-Eng x sVEGFR-1 direction of change between the 1st and 2nd trimesters | ||||||||||
| ≤ 0 | 151 | 4 | 1 | Reference | 28 | 1 | Reference | 95 | 1 | Reference |
| > 0 | 50 | 13 | 10.38 | 3.18-33.84 | 11 | 1.15 | 0.53-2.50 | 50 | 1.62 | 1.01-2.60 |
Odds ratios are estimated from a polytomous logistic regression model adjusted for BMI, maternal age and nulliparity, with additional adjustment for gestational age.
PlGF: placental growth factor; s-Eng: soluble endoglin; sVEGFR-1: soluble vascular endothelial growth factor receptor-1; SGA: small for gestational age.