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. Author manuscript; available in PMC: 2010 Mar 26.
Published in final edited form as: Biochem Soc Trans. 2007 Feb;35(Pt 1):18–22. doi: 10.1042/BST0350018

Figure 4. Effects of increased MMP-3 expression on mouse mammary epithelial cells.

Figure 4

(a) Increased genomic instability, shown as an increase in the rate of amplification at the CAD locus. FISH, fluorescence in situ hybridization; PALA, partition affinity ligand assay. (b) Cell shape changes caused by MMP-3-induced alterations in the actin cytoskeleton. Reproduced with permission from [13]. © 2005 Nature Publishing Group; http://www.nature.com