Phenomics |
Hematotoxicity |
CBC |
250 |
140 |
<1, <10, >10 |
Decrease in all blood cell counts |
Lan et al. 2004 [27] |
|
Colony |
24 |
29 |
<10, >10 |
Decrease in colony formation |
Lan et al. 2004 [27] |
Toxicogenomics |
Transcriptomics |
Affymetrix |
6 |
6 |
≥10 |
29 genes differentially expressed |
Forrest et al. 2005 [29] |
|
& q-PCR |
13 |
15 |
≥10 |
Validated 6 of 29 genes |
|
Affymetrix & Illumina |
8 |
8 |
|
Confirms Forrest findings |
McHale et al. 2009 [30] |
|
Illumina |
83 |
42 |
<1, <10, >10 |
Different gene pathways identified at low and high exposures |
McHale et al. 2008 [31] |
Proteomics |
SELDI-TOF |
20 |
20 |
31.3 & 37.9 (mean) |
Identified two down-regulated proteins as PF4 and CTAP-III |
Vermelen et al. 2005 [32] |
|
|
(2 sets of 10) |
|
|
|
Epigenomics |
DNA Methylation |
Illumina (GoldenGate) |
6 |
4 |
8.9±9.1 (mean±sd) |
Results preliminary (MSH3, RUNX3) |
Pilot Study |
|
|
Human TK6 Cells |
HQ (0, 10, 15, 20 μM) |
Results preliminary (RUNX1, IL12) |
|
miRNA |
Agilent |
7 |
7 |
<1 ppm |
Results preliminary (4 miRNAs) |
Pilot Study |
Genomics |
|
PDA in Yeast |
~4600 homozygous deletion strains |
HQ, CAT, BT |
Oxidative stress response |
North 2009 [44] |
|
RNAi |
WRN |
HQ |
DNA repair HR pathway |
Galvan 2008, Ren 2009 [48, 49] |
Genotyping |
|
Illumina (GoldenGate) |
250 |
140 |
0, < 1, < 10, > 10 |
Identified MPO, NQO1, and a group of DNA repair & cytokine genes |
Lan 2004, 2005, 2009, Shen 2006 [50–52] |