Table 1.
Antifungal activities of plakinic acids I-L (1–4). Minimum inhibitory concentration, MIC (μg/mL)a.
| 1 | 2 | 3 | 4 | |
|---|---|---|---|---|
| C. albicans, ATCC 14503 | 0.25 | 0.25 | 0.50 | 0.50 |
| C. albicans 96–489b | 0.06 | <0.03 | 0.12 | 0.12 |
| C. albicans UCD-FR1b | 0.25 | 0.12 | 0.50 | 0.50 |
| C. glabrata | 0.12 | 0.06 | 0.12 | 0.12 |
| C. krusei | 0.06 | 0.12 | 0.12 | 0.12 |
| Cryptococcus neoformans var. gattii | 0.12 | 0.25 | 0.12 | 0.50 |
| C. neoformans var. grubii | 0.12 | 0.25 | 0.12 | 0.50 |
a
The in vitro susceptibilities were determined by the microbroth dilution method according to the guidelines of the National Committee for Clinical Laboratory Standards (NCCLS).
b
Fluconazole-resistant (MIC >64 (μg/mL).