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. Author manuscript; available in PMC: 2011 Mar 26.
Published in final edited form as: J Nat Prod. 2010 Mar 26;73(3):373–377. doi: 10.1021/np9006876

Figure 1.

Figure 1

Structures and biosynthesis of natural and unnatural cyclomarin and cyclomarazine analogs. Supplementing cultures of the S. arenicola cymD− mutant with tryptophan analogs yields known and novel cyclomarins and cyclomarazines, thereby establishing 2 as the in vivo substrate for the heptamodular CymA NRPS. Thick arrows denote the pathway operative in wild type S. arenicola CNS-205, while thin lines represent pathways accessible via the cymD-deficient mutant. Abbreviations: A, adenylation domain; C, condensation domain; M1–M7, modules 1–7; MT, methyltransferase; T, thiolation domain; and TE, thioesterase.