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. Author manuscript; available in PMC: 2011 Mar 26.
Published in final edited form as: J Nat Prod. 2010 Mar 26;73(3):373–377. doi: 10.1021/np9006876

Figure 3.

Figure 3

Portion of an alignment of CymD with the active site of FgaPT2 and other prenyltransferases. Fungal indole prenyltransferases (PTases) from Aspergillus fumigatus FgaPT2 (accession no. AAX08549), CdpNPT (ABR14712), and FtmPT2 (AFUA_8G00250) were aligned with bacterial indole PTases CymD from Salinispora arenicola CNS-205 (SARE_4565) and LtxC (Lyngbya majuscula, AAT12285) and bacterial aromatic PTases NphB (Streptomyces sp. CL190, AB187169) and CloQ (Streptomyces roseochromogenes AF329398). Li and coworkers8 have identified the conserved residues in bold, two of which are lysines (*) responsible for the non-metal dependent activity of fungal indole PTases.