. Author manuscript; available in PMC: 2011 Mar 26.

Published in final edited form as: J Nat Prod. 2010 Mar 26;73(3):476–478. doi: 10.1021/np900608d

Table 3.

Comparison of the CD Spectra and Specific Rotation Values for the Reported Sclerosporins (+ and −) and Compounds 1 – 5.

	Compound	Δε Maxima and Minima in the CD Spectra (c 1.6 × 10⁻⁶ mol/L, MeOH)	Optical Rotation
(+)	(+)-sclerosporin⁷	Δε₁₉₆ + 11.0^a	[α]²⁰ _D + 11.4 (c 0.035, MeOH)
(−)	(−)-sclerosporin⁵	Δε₂₁₄ + 17.0^a	[α]²⁰ _D − 11.1 (c 0.090, MeOH)

(1)	(+)-sclerosporin	Δε₁₉₆ + 10.1, Δε₂₁₅ − 12.4	[α]²³ _D + 14 (c 0.033, MeOH)
(1)	(+)-sclerosporin		[α]²³ _D + 57 (c 0.033, CHCl₃)
(2)	(+)-15-hydroxy	Δε₁₉₇ + 5.2, Δε₂₁₄ − 14.8	[α]²³ _D + 64 (c 0.033, CHCl₃)
(3)	(+)-12-hydroxy	Δε₁₉₅ + 6.1, Δε₂₁₄ − 6.2	[α]²³ _D + 69 (c 0.033, CHCl₃)
(4)	(+)-11-hydroxy	Δε₁₉₈ + 3.2, Δε₂₁₃ − 16.3	[α]²³ _D + 73 (c 0.033, CHCl₃)
(5)	(−)-8-hydroxy	Δε₁₉₃ + 8.2, Δε₂₁₅ − 8.0	[α]²³ _D − 62 (c 0.033, CHCl₃)

Δε minima for + and − sclerosporin not reported in the literature