Figure 4.
Composition of plaques in ApoEā/ā mice exposed to 12 weeks of intermittent air control (IA) or intermittent hypoxia (IH). Representative images were obtained at the level of the aortic sinus above the valve cusps. Plaques in the IA, IA-WM (not shown) and IH group exhibited similar necrotic area (H&E), fibrosis (trichrome), macrophage area (mĪ¦), and smooth muscle actin content (SM-Actin). Levels of nitrotyrosine (3-NT) staining were also not different between IH and IA groups (A.U.= arbitrary units).