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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Biochim Biophys Acta. 2009 Jul 29;1804(5):1151–1166. doi: 10.1016/j.bbapap.2009.06.030

Figure 1.

Figure 1

Simplified models for template-dependent and template-independent DNA polymerase activity. (A) Most DNA polymerases require double-stranded DNA as a substrate, where the 5′→3′ strand is used as a primer and the complementary strand 3′→5′ is used as a template. (B) Terminal deoxynucleotidyl transferase is unique in its ability to catalyze phosphoryl transfer in the absence of a template that can not be accommodated in its active site.