Figure 1.
Schematic representation of the effects of transgenic expression of cyclooxygenase 2 (COX-2) in hepatocytes. The transgene protects against acute liver injury, but fails to alter the response to hepatocarcinogens, such as diethylnitrosamine (DEN). KC: Kupffer cell; HC: Hepatocyte; EC: Endothelial cell; HCC: Hepatocellular carcinoma; WT: Wild type; TG: COX-2 transgenic mice.