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. 2010 Mar 28;16(12):1430–1435. doi: 10.3748/wjg.v16.i12.1430

Figure 1.

Figure 1

Schematic representation of the effects of transgenic expression of cyclooxygenase 2 (COX-2) in hepatocytes. The transgene protects against acute liver injury, but fails to alter the response to hepatocarcinogens, such as diethylnitrosamine (DEN). KC: Kupffer cell; HC: Hepatocyte; EC: Endothelial cell; HCC: Hepatocellular carcinoma; WT: Wild type; TG: COX-2 transgenic mice.